بررسی رابطه بین تغییرات شاخص های فاز حاد التهاب با عوارض قلبی در مبتلایان به بیماری کاوازاکی

          Investigation of risk factors leading to cardiac complications in    Kawasaki disease is extremely important because coronary vasculitis may    lead to aneurysmal formation , stenosis and myocardial infarction. Various    laboratory and clinical parameters have been investigated in order to    find the predictive parameters and risk factors for such complications.           In present study we addressed the relationship between intensity of    acute phase response indicators(ESR, CRP, WBC and Platelet counts)  and    frequency of cardiovascular complications. 52 admitted children with    Kawasaki disease were included in this retrospective study. Data regarding    the intensity of acute phase reactants were recorded and relationships     between these markers and frequency of cardiovascular problems were    analyzed using statistical methods.           Various cardiovascular abnormalities were demonstrated in 13 cases    (25%) in whom, there were 11 cases with elevated ESR, 6 cases with positive    CRP, 2 cases with leukocytosis and 4 cases with thrombocytosis but in    comparison with non affected group , we didn’t find any significant    correlation between cardiovascular and intensity of acute phase responses.           The intensity of acute phase response indicators such as ESR, CRP, WBC    and Platelet counts can not be regarded as useful predictors for     cardiovascular complications of Kawasaki disease.